The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated molecular changes. Zebrafish Animal Model. The common fruit fly, Drosophila melanogaster , is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases. (2005). Rev. Zebrafish forward genetic screens: powerful approaches to identify new players in hematopoiesis. There is currently an unmet need for a therapy that promotes the regenerative process of remyelination in central nervous system diseases, notably multiple sclerosis (MS). Animal models have been an invaluable means to advance biomedical research as they provide experimental avenues for cellular and molecular investigations of disease pathology. Marta Prat Coll 5, pp. Animal models of human disease zebrafish swim into view • First, human pathogens cause disease at 37°C, whereas zebrafish are maintained at 28°C; it might not be possible, therefore, to study some pathogens at this lower temperature. This review highlights the achievements and potential of zebrafish for modelling human cancer and for peptide … There are many different animal models, ranging from flies to monkeys to mice, which are used to investigate human disease. The zebrafish, Danio rerio, has emerged as a leading vertebrate model organism to study human diseases and biological effects of various chemicals (Lieschke and Currie, 2007). ... Rubinstein AL. Animals that are chosen to model human diseases will often have similar physiology or some other similar aspect relating to human genetics. While zebrafish have for some time been regarded as a powerful model organism with which to study early events in hematopoiesis, recent evidence suggests that it also ideal for unraveling the molecular requirements for T cell development in the thymus. Traditional biotechnology in animal models included the mixtures of random genes. Nat Rev Genet 8: 353–367. - PubMed Voelker D, Vess C, Tillmann M, Nagel R, Otto GW, et al. A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Genet. As a model of whole organism, zebrafish provide a means to develop promising peptide and protein anticancer agents in an informative, cost-effective and time-efficient manner, which also allows for surveying mechanisms of drug action and optimization of drug delivery system. 2007 Animal models of human disease: zebrafish swim into view. Physiol Genomics 2: 49–51. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. ... Cre/ lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Animal models of human disease: zebrafish swim into view. The zebrafish (Danio rerio) is used as a model vertebrate in developmental biology and for modeling human disease. 17. 8. Overview of attention for article published in Nature Reviews Genetics, May 2007 . Currie, Animal models of human disease: zebrafish swim into view. Insights into tuberculosis form the zebrafish model 18: 689-690 7.Lieschke G.J., et al. The strong correlation between the embryonic zebrafish and developmental rat/rabbit studies could be readily anticipated as zebrafish is widely documented to rival or exceed the utility of rodents for the modeling of a growing list of human diseases (Lieschke and Currie, 2007; Santoriello and Zon, 2012; Scholz, 2013). 2007 May;8(5):353-67. doi: 10.1038/nrg2091. Nat. ish,” and Lieschke and Currie (2007) said, “Animal models of human disease: zebrafish swim into view.” THE ZEBRAFISH GENOME The genome of zebrafish, a small freshwater vertebrate, consists of 25 chromosomes and contains essentially the full repertoire of vertebrate genes. Lieschke GJ, Currie PD (2007) Animal models of human disease: Zebrafish swim into view. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. Postlethwait JH, Yan YL, Gates MA, et al. Although the in vitro cell cultures tests are widely used, the results may not generate actual forecasts compared with in vivo results. (2000). Lieschke, P.D. 8, no. Currie, Animal models of human disease: zebrafish swim into view. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. 8(5), 353–367 (2007).Crossref, Medline, CAS, Google Scholar; 21 Howe K, Clark MD, Torroja CF et al. Zurück zum Zitat G.J. Nat Rev Genet. Animal models of human disease: zebrafish swim into view. 8. Zebrafish (wild-type, Danio rerio) were maintained at 28°C in a 13 h light and 11 h dark cycle. Barut BA, Zon LI (2000) Realizing the potential of zebrafish as a model for human disease. Berger S, Cole NJ, Hall TE, Currie PD disease and... From MS lesions diseases will often have similar physiology or some other similar aspect relating to Genetics! 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